2. シグナル伝達
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

製品番号 製品名 製品効果 純度 構造式
  • HY-W053507S
    m-Tolylacetic acid-d3
    m-Tolylacetic acid-d3 (3-Methylbenzeneacetic acid-d3) is the deuterium labeled m-Tolylacetic acid (HY-W053507). m-Tolylacetic acid is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid. m-Tolylacetic acid can be used for drug intermediate for synthesising more complex molecules.
    m-Tolylacetic acid-d<sub>3</sub>
  • HY-W587436
    N-Acetyl-S-(carbamoylethyl)-L-cysteine
    N-Acetyl-S-(2-carbamoylethyl) -L-cysteine is the urinary metabolite of acrylamide in humans, and its association with other diseases.
    N-Acetyl-S-(carbamoylethyl)-L-cysteine
  • HY-W653919
    SN-38 glucuronide-d3
    SN-38 glucuronide-d3 is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.
    SN-38 glucuronide-d<sub>3</sub>
  • HY-130318
    Quinidine N-oxide
    Quinidine N-oxide is a pharmacologically inactive metabolite of Quinidine (HY-B1751H). Quinidine is an active probe of CYP3A4.
    Quinidine N-oxide
  • HY-103687R
    Abiraterone metabolite 1 (Standard)
    Abiraterone metabolite 1 (Standard) is the analytical standard of Abiraterone metabolite 1. This product is intended for research and analytical applications. Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal agent, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
    Abiraterone metabolite 1 (Standard)
  • HY-N12462
    Glycochenodeoxycholic acid 3-sulfate
    Glycochenodeoxycholic acid 3-sulfate (GCDCA-S; 3-Sulfate-GCDCA) is a. Glycochenodeoxycholic acid 3-sulfate can serve as hepatocellular carcinoma biomarker.
    Glycochenodeoxycholic acid 3-sulfate
  • HY-131422
    (Rac)-8-Hydroxy-efavirenz
    (Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz (HY-10572), a non-nucleoside HIV-1 reverse transcriptase inhibitor.
    (Rac)-8-Hydroxy-efavirenz
  • HY-W010115
    Carbofuran phenol 99.75%
    Carbofuran phenol is a hydrolytic metabolite of the Carbofuran pesticide. Carbofuran phenol is promising for research of environmental bioremediation fields.
    Carbofuran phenol
  • HY-W324493
    Carboxymefloquine
    Carboxymefloquine is a metabolite of Mefloquine (HY-17437) (an antimalarial agent). Carboxymefloquine can be used in malaria research.
    Carboxymefloquine
  • HY-121745R
    Phosmet oxon (Standard)
    Phosmet oxon (Standard) is the analytical standard of Phosmet oxon. This product is intended for research and analytical applications. Phosmet oxon (Imidoxon) is a main and toxic metabolite of phosmet. Phosmet is a cholinesterase inhibitor insecticide used on pome and stone fruits.
    Phosmet oxon (Standard)
  • HY-W016388R
    9-Fluorenol (Standard)
    9-Fluorenol (Standard) is the analytical standard of 9-Fluorenol. This product is intended for research and analytical applications. 9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 μM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo.
    9-Fluorenol (Standard)
  • HY-Z8537
    Desmethyl mirtazapine hydrochloride
    Desmethyl mirtazapine (Normirtazapine) hydrochloride is a metabolite of Mirtazapine (HY-B0352). Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent.
    Desmethyl mirtazapine hydrochloride
  • HY-133010R
    Tamoxifen N-oxide (Standard)
    Cyclanilide (Standard) is the analytical standard of Cyclanilide. This product is intended for research and analytical applications. Cyclanilide (RPA90946) serves as a plant growth regulator that is applied to cotton during various growth stages.
    Tamoxifen N-oxide (Standard)
  • HY-W585923
    Clethodim sulfoxide
    Clethodim sulfoxide is the aerobic metabolite of clethodim (HY-119896), a cyclohexanedione oxime herbicide.
    Clethodim sulfoxide
  • HY-W422362
    Carbocysteine sulfoxide
    Carbocysteine sulfoxide is a metabolite and impurity of Carbocisteine (HY-D0205A).
    Carbocysteine sulfoxide
  • HY-A0255
    Clocortolone
    Clocortolone is a synthetic glucocorticoid steroid and corticosteroid ester. Clocortolone can be used for seborrheic dermatitis, contact dermatitis, atopic dermatitis, and psoriasis. Clocortolone has local in vivo potency and is not easily absorbed into systemic circulation.
    Clocortolone
  • HY-116513R
    Adrenochrome (Standard)
    Adrenochrome (Standard) is the analytical standard of Adrenochrome. This product is intended for research and analytical applications.
    Adrenochrome (Standard)
  • HY-100657R
    meta-Fexofenadine (Standard)
    meta-Fexofenadine (Standard) is the analytical standard of meta-Fexofenadine. This product is intended for research and analytical applications. meta-Fexofenadine (meta-MDL-16455) is an impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.
    meta-Fexofenadine (Standard)
  • HY-W070554
    1-(Hydroxymethyl)-5,5-dimethylhydantoin
    1-(Hydroxymethyl)-5,5-dimethylhydantoin is a degradation product of 1,3-dimethylol-5,5-dimethylhydantoin, which is a formaldehyde-releasing antimicrobial preservative.
    1-(Hydroxymethyl)-5,5-dimethylhydantoin
  • HY-130239S
    14(S)-HDHA-d5
    14(S)-HDHA-d5 (14(S)-HDoHE-d5) is deuterium labeled 14(S)-HDHA. 14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway.
    14(S)-HDHA-d<sub>5</sub>
製品番号 製品名 / Synonyms Application Reactivity